Hypertension's association with sexual dysfunction falls under the kidney deficiency syndrome umbrella in TCM, often manifesting as kidney Yin deficiency. Earlier research efforts by multiple research groups showcased that Yin-enriching and kidney-tonifying methods could contribute to reduced blood pressure, improved sexual function, the reversal of risk factors, and the preservation of target organs. This article explored the traditional Chinese medicine viewpoint, modern pathophysiological mechanisms, and treatment strategies for kidney-tonifying drugs (individual and combined) in addressing hypertension and its accompanying sexual dysfunction, furnishing a scientifically sound basis for kidney-tonifying approaches in this complex clinical scenario.
Within the orthopaedic and traumatology department, fractures are a common medical issue. Jiegu Qili Tablets (Capsules), a Chinese patent medicine, is a commonly used treatment for fractures in clinical practice and is listed as a Class A drug covered by the national medical insurance system. Yet, no established consensus or detailed guidelines, rooted in evidence, currently directs clinicians in the use of this medication, thus hindering its clinical impact. In accordance with the expert consensus on clinical applications of proprietary Chinese medicines, a consensus was reached, prioritizing evidence, supplementing with consensus, and referencing experience. In light of both a literature review and a questionnaire survey, a timely summary of existing clinical evidence pertaining to the use of Jiegu Qili Tablets (Capsules) in fracture treatment was constructed, incorporating the clinical insights of several prominent experts. Cell Isolation Following a process spanning more than a year, the China Association of Chinese Medicine, in September 2021, unveiled the consensus (GS/CACM 293-2021). This consensus document was developed with the participation of multidisciplinary experts from 27 organizations representing a blend of Chinese and Western medicine research institutions. This article provides a detailed account of the background and intentions behind the consensus, and a description of the key steps involved in the proposal, drafting, expert agreement, and consultation process. Five consensus recommendations and twelve consensus suggestions, pertaining to the key areas of indications, treatment timing, dosage, duration, and safety in the clinical application of Jiegu Qili Tablets (Capsules) for fracture treatment, facilitate rational use by clinicians, thus improving accuracy and safety.
A review of systematic reviews/meta-analyses (SR/MAs) of Chinese herbal injections for sepsis was undertaken in this study, with the goal of supporting clinical practice and bolstering the quality of clinical evidence. An electronic search across eight Chinese and English databases, including CNKI, Medline, and EMbase, was performed to identify systematic reviews/meta-analyses (SR/MAs) of Chinese herbal injections for sepsis, spanning from database inception to June 2022. Applying AMSTAR 2, PRISMA 2020, the GRADE system, and the Recommendations for Clinical Evidence Grading on Traditional Chinese Medicine Based on Evidence Body, the study evaluated the quality of evidence, the reporting, and methodology of the included articles. From the SR/MA corpus, 27 articles were selected, which included four Chinese herbal injections, namely Xuebijing, Shenfu, Shenmai, and Shengmai. The methodological quality of the systematic review/meta-analysis, as assessed by the AMSTAR 2 checklist, was found to be between moderate and very low. Item 2 (prior study design) garnered significantly low scores, as did less significant items 3 (study design selection reasoning), 10 (description of funding sources), and 16 (disclosure of conflicts of interest). In line with PRISMA 2020 criteria, eight thematic categories showcasing full reporting of missing data exceeding 50% include search methods, certainty evaluations, synthesis outcomes, confidence in evidence, registration and protocol details, supporting documentation, potential conflicts of interest, data availability, and accessibility of code and other materials. Included in the SR/MA were 30 distinct outcome indicators. Evidence-based assessments of mortality, APACHE score, and safety, the three key outcome indicators, were conducted, and each received a medium rating. The lack of randomization in the allocation process, the absence of allocation concealment techniques, blinding protocols, and a sufficient sample size all contributed to the diminished evidence level. The evidence indicates that Chinese herbal injections may function as a safe and effective supplemental therapy for sepsis, mitigating mortality, reducing inflammation, improving coagulation function, and regulating immune response, tissue perfusion, and oxygenation levels in patients with sepsis. The SR/MA results were not of sufficient quality, requiring more high-quality SR/MA to establish the efficacy and safety of Chinese herbal injections in treating sepsis.
Using a systematic approach, this study examined the clinical impact and safety profile of Fengliao Changweikang in individuals with acute gastroenteritis (AGE). Monomethyl auristatin E manufacturer In order to collect randomized controlled trials (RCTs) on the treatment of AGE with the Fengliao Changweikang prescription, searches were conducted in the CNKI, Wanfang, VIP, SinoMed, Medline, Cochrane Library, and two clinical trial registration platforms databases from their inception dates to August 30, 2022. Independent literature screening, data extraction, and risk of bias assessment were undertaken by two researchers, guided by predefined inclusion and exclusion criteria. The data underwent analysis using RevMan 54.1 as the analytical platform. Ultimately, eighteen randomized controlled trials were selected, comprising 3,489 patients. Using the Fengliao Changweikang prescription in conjunction with conventional Western medicine resulted in an increased cure rate (RR = 143, 95% CI [112, 182], P = 0.0004), and a reduction in diarrhea duration (RR = -165, 95% CI [-244, -086], P < 0.00001). To summarize, the Fengliao Changweikang prescription proved safe during clinical use. AGE patients experienced a beneficial result through the mitigation of diarrhea, abdominal pain, vomiting, and fever, as well as the decrease in certain serum inflammatory factors. Although few high-quality studies have examined the treatment of AGE using the Fengliao Changweikang prescription, its potential efficacy and safety warrant further investigation in future studies.
An investigation into the pharmacokinetic and tissue distribution disparities of four alkaloids in Ermiao Pills and Sanmiao Pills, comparing normal and arthritic rat models, was undertaken in this work. To evaluate the effects of Ermiao Pills and Sanmiao Pills, a rat arthritis model was developed using Freund's complete adjuvant. Four alkaloids were quantified in plasma and tissue samples from both normal and arthritic rats post-treatment via ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in positive ion multiple reaction monitoring (MRM) mode. Comparing the pharmacokinetic and tissue distribution variations of the four active constituents involved in the study, the researchers explored the effect of Achyranthis Bidentatae Radix on the primary components of Sanmiao Pills. This study introduced an UPLC-MS/MS method capable of simultaneously determining four alkaloids, with the method's metrics for specificity, linearity, accuracy, precision, and stability satisfying the required parameters. In model rats, the pharmacokinetic study following Ermiao Pill administration indicated a significant decrease in the area under the curve (AUC) and maximum concentration (Cmax) of phellodendrine, magnoflorine, berberine, and palmatine, in contrast to normal rats. Simultaneously, a substantial rise in the clearance rate (CL/F) was observed, along with a significant decrease in the distribution and tissue/plasma concentration ratio of the four alkaloids in the liver, kidney, and joint tissues. In arthritic rats, the administration of Achyranthis Bidentatae Radix resulted in a pronounced elevation of the AUC of phellodendrine, berberine, and palmatine, a concurrent reduction in their clearance rates, and a substantial increase in their deposition within the liver, kidney, and joints. Although this occurred, the pharmacokinetics and tissue distribution of the four alkaloids in normal rats showed no notable effect. These findings imply that Achyranthis Bidentatae Radix, a component of Sanmiao Pills, may facilitate meridian regulation by improving the distribution of active ingredients within tissues, particularly under arthritic conditions.
Gigantol, a phenolic substance found in the valuable Chinese medicinal herb Dendrobii Caulis, displays diverse pharmacological properties, including the prevention of cancerous tumors and diabetic cataracts. This research project focused on investigating the intricate molecular mechanism of gigantol's participation in transmembrane transport within human lens epithelial cells (HLECs). In vitro-cultured immortalized HLECs were dispensed into laser scanning confocal microscopy (LSCM) medium at a concentration of 5,000 cells per milliliter. HLECs containing fluorescently labeled gigantol exhibited varied fluorescence distribution and intensity, which were evaluated via LSCM. Gigantol's absorption and distribution were ascertained by quantifying the observed fluorescence intensity. Studies were performed to observe the transmembrane transport mechanisms of gigantol in HLECs. Comparisons were made concerning the effects of time, temperature, concentration, transport inhibitors, and diverse cell lines on the transmembrane absorption and transport of gigantol. Atomic force microscopy (AFM) revealed the ultrastructure of HLECs, which were first inoculated onto the climbing surfaces of 6-well culture plates, during their transmembrane absorption of non-fluorescently labeled gigantol. Antipseudomonal antibiotics Analysis of the results showed a relationship between the transmembrane absorption of gigantol and both time and concentration. This absorption pattern specifically targeted HLECs.